SCHEMBL19909875

SCHEMBL19909875

CCc1cccc(N(N)C(=O)N(C)N)c1COc1ccn(-c2ccc(Cl)cc2)n1

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 1/20 0.37
SIGMAR1 Q99720 5/20 0.36
ALDH1A1 P00352 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
TRPA1 O75762 1/20 0.34
KDM4E B2RXH2 2/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
KCNH2 Q12809 1/20 0.32
CTDSP1 Q9GZU7 1/20 0.32
KMT2A Q03164 2/20 0.31
AGTR1 P30556 1/20 0.31
LMNA P02545 1/20 0.31
MEN1 O00255 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
PARP1 P09874 1/20 0.30
PARP2 Q9UGN5 1/20 0.30
PARP3 Q9Y6F1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22563938 0.94 NR1H4 (0.35) NR1H4SIGMAR1ALDH1A1CYP1A2CYP3A4
SCHEMBL22563863 0.91 KDM4E (0.35) NR1H4KDM4ENPC1RAB9AKMT2A
SCHEMBL22564123 0.90 NR1H4 (0.36) NR1H4SIGMAR1ALDH1A1CYP1A2CYP3A4
SCHEMBL22563896 0.88 SIGMAR1 (0.40) NR1H4SIGMAR1ALDH1A1CYP1A2CYP3A4
SCHEMBL22564135 0.86 NR1H4 (0.37) NR1H4SIGMAR1ALDH1A1CYP1A2CYP3A4
SCHEMBL22564019 0.83 NR1H4 (0.33) NR1H4SIGMAR1
SCHEMBL22564156 0.83 NR1H4 (0.36) NR1H4SIGMAR1ALDH1A1CYP1A2CYP3A4
SCHEMBL22563756 0.81 DGAT1 (0.34) NR1H4ALDH1A1CYP3A4NPC1RAB9A
SCHEMBL22563751 0.81 KDM4E (0.34) NR1H4ALDH1A1KDM4ENPC1RAB9A
SCHEMBL19909868 0.80 ALDH1A1 (0.35) NR1H4ALDH1A1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3025585-B1 PLANT DISEASE CONTROL COMPOSITION AND ITS USE SUMITOMO CHEMICAL CO (JP) 2018-02-28 EP disclosed