SCHEMBL19913101

SCHEMBL19913101

Cc1ccc2c(c1)c1ccccc1n2-c1cc(C#N)c(-n2c3ccccc3c3cc(C(F)(F)F)ccc32)cc1-c1ccncc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
RECQL P46063 1/20 0.36
KMT2A Q03164 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
KIF11 P52732 2/20 0.35
HRH1 P35367 2/20 0.35
HTR6 P50406 2/20 0.35
S1PR1 P21453 1/20 0.34
S1PR3 Q99500 1/20 0.34
ABCG2 Q9UNQ0 1/20 0.33
XDH P47989 1/20 0.33
GPBAR1 Q8TDU6 2/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33
METAP2 P50579 1/20 0.33
PIK3CA P42336 1/20 0.33
PIK3CB P42338 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19913102 0.96 KIF11 (0.36) KDM4EMEN1ALDH1A1LMNAMAPT
SCHEMBL19909072 0.94 ABCG2 (0.36) KIF11HRH1HTR6ABCG2GPBAR1
SCHEMBL19908934 0.91 ALDH1A1 (0.43) KDM4EMEN1ALDH1A1LMNAMAPT
SCHEMBL19919621 0.90 KIF11 (0.38) KDM4ELMNAKIF11HRH1HTR6
SCHEMBL19913119 0.90 S1PR1 (0.37) S1PR1S1PR3XDHCYP19A1CYP11B1
SCHEMBL19913104 0.88 XDH (0.35) KDM4ELMNAKIF11XDHMETAP2
SCHEMBL19909074 0.88 KIF11 (0.41) KIF11ABCG2METAP2CYP19A1CYP11B1
SCHEMBL19909040 0.88 METAP2 (0.39) KIF11HRH1HTR6ABCG2XDH
SCHEMBL19912422 0.88 KIF11 (0.36) KDM4EKIF11HRH1HTR6XDH
SCHEMBL20923118 0.87 METAP2 (0.38) KDM4EALDH1A1MAPTNPSR1KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180062085-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2018-03-01 US disclosed