Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856783 | 0.72 | CNR1 (0.51) | MEN1KMT2AMAPK1TRPV1 | |
| SCHEMBL22105981 | 0.64 | ADH1B (0.37) | MEN1KMT2AMAPK1LMNAPOLB | |
| SCHEMBL15171012 | 0.63 | FLT1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31292987 | 0.61 | MTNR1A (0.64) | MEN1KMT2ALMNA | |
| SCHEMBL2471353 | 0.61 | LMNA (0.65) | MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL2473716 | 0.61 | TAAR1 (0.62) | MEN1KMT2A | |
| SCHEMBL15170970 | 0.61 | LMNA (0.37) | LMNAPOLB | |
| SCHEMBL15099560 | 0.61 | HTR2A (0.41) | MEN1KMT2AMAPK1LMNAL3MBTL1 | |
| SCHEMBL21541005 | 0.61 | NPC1 (0.44) | MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5073548 | 0.61 | ALDH1A1 (0.54) | MEN1KMT2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374796-B1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorderes | ARENA PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |