Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917655 | 0.90 | LMNA (0.40) | RXRARXRBRXRGTRPA1TACR1 | |
| SCHEMBL19917754 | 0.89 | MAPT (0.42) | MAPTRXFP1RXRARXRBRXRG | |
| SCHEMBL19917716 | 0.87 | TRPA1 (0.41) | MAPTRXFP1RXRARXRBRXRG | |
| SCHEMBL19917729 | 0.87 | LMNA (0.48) | GAALMNARAB9AMEN1KMT2A | |
| SCHEMBL16894225 | 0.82 | TRPA1 (0.53) | TP53TRPA1GAAALDH1A1KMT2A | |
| SCHEMBL19917689 | 0.81 | LMNA (0.41) | TRPA1LMNAALDH1A1RAB9ACASR | |
| SCHEMBL19917735 | 0.81 | TRPA1 (0.40) | MAPTRXFP1RXRARXRBRXRG | |
| SCHEMBL19917776 | 0.81 | TRPA1 (0.45) | TRPA1LMNA | |
| SCHEMBL19917767 | 0.80 | BACE1 (0.54) | MAPTTRPA1GAALMNAALDH1A1 | |
| SCHEMBL19917753 | 0.80 | TRPA1 (0.41) | MAPTRXFP1RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |