Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917729 | 0.91 | LMNA (0.48) | LMNABACE1BACE2OPRM1OPRL1 | |
| SCHEMBL19917734 | 0.90 | MAPT (0.41) | LMNATRPA1TACR1RAB9ARXRA | |
| SCHEMBL19917670 | 0.86 | TRPA1 (0.44) | LMNATRPA1TACR1CCR2BACE1 | |
| SCHEMBL19917689 | 0.85 | LMNA (0.41) | LMNATRPA1OPRM1OPRL1NPC1 | |
| SCHEMBL19917776 | 0.85 | TRPA1 (0.45) | LMNATRPA1PPARAPPARD | |
| SCHEMBL19917767 | 0.84 | BACE1 (0.54) | LMNATRPA1BACE1BACE2OPRM1 | |
| SCHEMBL16894244 | 0.80 | TRPA1 (0.56) | TRPA1POLBALDH1A1 | |
| SCHEMBL19917781 | 0.79 | TRPA1 (0.41) | LMNATRPA1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL19917653 | 0.79 | TRPA1 (0.38) | TRPA1TACR1CCR2BACE1BACE2 | |
| SCHEMBL19917761 | 0.79 | LMNA (0.53) | LMNABACE1BACE2OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |