Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917729 | 0.90 | LMNA (0.48) | BACE1LMNAMEN1KMT2APOLB | |
| SCHEMBL19917655 | 0.84 | LMNA (0.40) | BACE1ALDH1A1LMNAPOLBBACE2 | |
| SCHEMBL19917689 | 0.82 | LMNA (0.41) | ALDH1A1LMNAPOLBHPGDOPRM1 | |
| SCHEMBL19917776 | 0.82 | TRPA1 (0.45) | LMNATRPA1 | |
| SCHEMBL19917781 | 0.81 | TRPA1 (0.41) | ALDH1A1LMNAL3MBTL1OPRM1OPRL1 | |
| SCHEMBL16894086 | 0.80 | ALDH1A1 (0.65) | BACE1ALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL19917734 | 0.80 | MAPT (0.41) | ALDH1A1LMNAMEN1MAPTKMT2A | |
| SCHEMBL19917763 | 0.80 | BACE1 (0.52) | BACE1ALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL19917705 | 0.79 | TRPA1 (0.51) | BACE1ALDH1A1LMNAL3MBTL1OPRM1 | |
| SCHEMBL19917761 | 0.78 | LMNA (0.53) | BACE1ALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |