Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | KLRK1 | P26718 | 3/20 | 0.35 |
| ▸ | MICA | Q29983 | 3/20 | 0.35 |
| ▸ | RAET1L | Q5VY80 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917762 | 0.83 | NPC1 (0.46) | KMT2AMEN1PTGER1OPRM1OPRL1 | |
| SCHEMBL16894219 | 0.83 | KMT2A (0.52) | KMT2AMEN1PTGER1ALDH1A1GAA | |
| SCHEMBL19917765 | 0.83 | TRPA1 (0.47) | KMT2ATRPA1 | |
| SCHEMBL19917770 | 0.82 | LMNA (0.38) | KMT2AMEN1PTGER1ALDH1A1HTR7 | |
| SCHEMBL19917704 | 0.82 | TRPA1 (0.50) | KMT2AMEN1ALDH1A1TRPA1OPRM1 | |
| SCHEMBL19917764 | 0.81 | CASR (0.39) | KMT2AMEN1PTGER1HTR7HTR1A | |
| SCHEMBL19917753 | 0.75 | TRPA1 (0.41) | KMT2AMEN1ALDH1A1GAATRPA1 | |
| SCHEMBL16894218 | 0.74 | KMT2A (0.41) | KMT2AMEN1HTR7HTR1ADRD2 | |
| SCHEMBL19917751 | 0.74 | TRPA1 (0.42) | P2RX7TRPA1 | |
| SCHEMBL19917755 | 0.73 | TRPA1 (0.47) | KMT2ATRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |