Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 5/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995348 | 0.96 | ADRA1A (0.46) | TOP2AADRA1AHRH3HRH1ADRA1B | |
| SCHEMBL13013370 | 0.84 | ADRA1A (0.43) | TOP2AADRA1AHRH3HRH1ADRA1B | |
| SCHEMBL1993828 | 0.84 | RECQL (0.55) | TOP2AADRA1AHRH3KDM4ECYP2D6 | |
| SCHEMBL13013360 | 0.83 | HTR3A (0.45) | CNR1ICMTKDM4ETSHRHSD17B10 | |
| SCHEMBL1992765 | 0.80 | RECQL (0.56) | ADRA1AHRH3HRH1ADRA1BKDM4E | |
| SCHEMBL13013352 | 0.76 | CNR1 (0.43) | CNR1ICMTKDM4ETSHRHSD17B10 | |
| SCHEMBL2588997 | 0.76 | KDM4E (0.46) | ICMTKDM4ETSHRPOLBMAPT | |
| SCHEMBL1994502 | 0.73 | ROCK2 (0.44) | ADRA1AHRH1ADRA1BCNR1KDM4E | |
| SCHEMBL1992793 | 0.72 | PADI4 (0.45) | CNR1HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL1992796 | 0.72 | PADI4 (0.45) | CNR1HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110152243-A1 | NOVEL THIENOPYRROLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152243-A1 | NOVEL THIENOPYRROLE COMPOUNDS | TPMT, TSLP, THPO | TOP2A 2466/4885ADRA1A 272/4885HRH3 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.