Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21116501 | 0.81 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 | |
| SCHEMBL14909745 | 0.81 | ALOX5 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 | |
| SCHEMBL14909743 | 0.81 | ALOX5 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 | |
| SCHEMBL29433052 | 0.80 | CHRNB2 (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 | |
| SCHEMBL29433062 | 0.80 | CHRNB2 (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 | |
| SCHEMBL19926247 | 0.80 | CHRNB2 (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 | |
| Hydrochloric Acid SCHEMBL29433046 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 | |
| Hydrochloric Acid SCHEMBL28704545 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 | |
| Hydrochloric Acid SCHEMBL28698062 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 | |
| Hydrochloric Acid SCHEMBL29433049 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11198685-B2 | Substituted ureas and methods of making and using same | MEBIAS DISCOVERY, INC. (US) | 2021-12-14 | — | — | US | disclosed |
| US-20200308155-A1 | Substituted Ureas and Methods of Making and Using Same | MEBIAS DISCOVERY, INC. | 2020-10-01 | — | — | US | disclosed |
| US-10683283-B2 | Substituted ureas and methods of making and using same | MEBIAS DISCOVERY, INC. (US) | 2020-06-16 | — | — | US | disclosed |
| EP-3506983-A1 | SUBSTITUTED UREAS AND METHODS OF MAKING AND USING SAME | Mebias Discovery LLC (US) | 2019-07-10 | — | — | EP | disclosed |
| US-20190194178-A1 | SUBSTITUTED UREAS AND METHODS OF MAKING AND USING SAME | MEBIAS DISCOVERY LLC | 2019-06-27 | — | — | US | disclosed |
| WO-2018045229-A1 | SUBSTITUTED UREAS AND METHODS OF MAKING AND USING SAME | MEBIAS DISCOVERY LLC (US) | 2018-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683283-B2 | Substituted ureas and methods of making and using same | UMPS, METTL3, UTS2R | CHRNB2 3615/4885CHRNB4 3852/4885CHRNA3 2522/4885 |
| US-20190194178-A1 | SUBSTITUTED UREAS AND METHODS OF MAKING AND USING SAME | UMPS, METTL3, UTS2R | CHRNB2 3615/4885CHRNB4 3852/4885CHRNA3 2522/4885 |
| US-11198685-B2 | Substituted ureas and methods of making and using same | UMPS, METTL3, UTS2R | CHRNB2 3615/4885CHRNB4 3852/4885CHRNA3 2522/4885 |
| US-20200308155-A1 | Substituted Ureas and Methods of Making and Using Same | UMPS, METTL3, UTS2R | CHRNB2 3615/4885CHRNB4 3852/4885CHRNA3 2522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.