Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006545 | 0.85 | MAPT (0.42) | MEN1KMT2AMAPTRAB9AMMP13 | |
| SCHEMBL10623305 | 0.79 | RAB9A (0.57) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL1992688 | 0.75 | TUBB4A (0.43) | KMT2AMAPTALDH1A1L3MBTL1POLB | |
| SCHEMBL10814360 | 0.75 | LMNA (0.49) | MEN1KMT2AMAPK1CMA1L3MBTL1 | |
| SCHEMBL30939550 | 0.72 | CYP2C9 (0.61) | MEN1KMT2ARAB9AMAPK1NTRK1 | |
| SCHEMBL30939620 | 0.72 | LMNA (0.45) | MEN1KMT2AMAPTRAB9ATSHR | |
| SCHEMBL1978190 | 0.72 | LMNA (0.45) | MEN1KMT2AMAPTRAB9ATSHR | |
| SCHEMBL15547384 | 0.72 | CYP2C9 (0.61) | MEN1KMT2ARAB9AMAPK1NTRK1 | |
| SCHEMBL17913022 | 0.71 | MEN1 (0.40) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL1979667 | 0.71 | SMN1; SMN2 (0.58) | MEN1KMT2AMAPTRAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509961-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | Autifony Therapeutics Limited (GB) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011069951-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |