Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992687 | 0.85 | MEN1 (0.41) | MAPTALDH1A1TSHRMAPK1NTRK1 | |
| SCHEMBL10623305 | 0.77 | RAB9A (0.57) | MAPTALDH1A1HSD17B10RAB9AMEN1 | |
| SCHEMBL5324510 | 0.76 | THRB (0.38) | MAPTALDH1A1HSD17B10RAB9AMCHR1 | |
| SCHEMBL10814360 | 0.73 | LMNA (0.49) | MAPK1CA2MEN1KMT2AMCHR1 | |
| SCHEMBL10614477 | 0.73 | ALDH1A1 (0.62) | MAPTALDH1A1TSHRMAPK1HSD17B10 | |
| SCHEMBL16316320 | 0.72 | LTA4H (0.52) | MAPTALDH1A1MAPK1NTRK1IGF1R | |
| SCHEMBL12523255 | 0.71 | MGLL (0.46) | MAPTALDH1A1TSHRMAPK1IGF1R | |
| SCHEMBL17913022 | 0.70 | MEN1 (0.40) | MAPTALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL11380761 | 0.68 | MEN1 (0.59) | MAPTMEN1KMT2A | |
| SCHEMBL31172821 | 0.68 | APLNR (0.66) | MAPTALDH1A1HSD17B10CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509961-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | Autifony Therapeutics Limited (GB) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011069951-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |