SCHEMBL19929101

SCHEMBL19929101

Nc1nc2[nH]cc(CNC3C=CC(O)C3O)c2c(=O)[nH]1

nearest known ligand 0.51

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TYMS P04818 8/20 0.41
FOLR1 P15328 1/20 0.39
SLC19A1 P41440 1/20 0.39
SLC46A1 Q96NT5 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL93906 1.00 TYMS (0.41) TYMSFOLR1SLC19A1SLC46A1
SCHEMBL21343009 1.00 TYMS (0.41) TYMSFOLR1SLC19A1SLC46A1
SCHEMBL19929273 1.00 TYMS (0.41) TYMSFOLR1SLC19A1SLC46A1
SCHEMBL19929270 1.00 TYMS (0.41) TYMSFOLR1SLC19A1SLC46A1
SCHEMBL19929275 1.00 TYMS (0.41) TYMSFOLR1SLC19A1SLC46A1
SCHEMBL23005880 1.00 TYMS (0.41) TYMSFOLR1SLC19A1SLC46A1
SCHEMBL15972267 0.84 PNP (0.32)
Hydrochloric Acid SCHEMBL29354653 0.83 PNP (0.32)
SCHEMBL21343010 0.82 TYMS (0.41) TYMSFOLR1SLC19A1SLC46A1
SCHEMBL23109473 0.82 TYMS (0.40) TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11684611-B2 Compounds for treating diseases associated with a mitochondrial dysfunction AMABIOTICS (FR) 2023-06-27 US disclosed
US-11684611-B2 Compounds for treating diseases associated with a mitochondrial dysfunction AMABIOTICS (FR) 2023-06-27 US disclosed
US-20230040247-A1 COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES AMABIOTICS (FR) 2023-02-09 US disclosed
WO-2021048430-A1 COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES AMABIOTICS (FR) 2021-03-18 WO disclosed
WO-2021048431-A1 COMPOUNDS FOR TREATING ATAXIA AMABIOTICS (FR) 2021-03-18 WO disclosed
US-20210052589-A1 COMPOUNDS FOR TREATING ALZHEIMER'S DISEASE AMABIOTICS (FR) 2021-02-25 US disclosed
US-20210046056-A1 Compounds for Treating Diseases Associated with a Mitochondrial Dysfunction AMABIOTICS (FR) 2021-02-18 US disclosed
US-10857135-B2 Compounds for treating diseases associated with a mitochondrial dysfunction AMABIOTICS (FR) 2020-12-08 US disclosed
WO-2019170834-A1 COMPOUNDS FOR TREATING ALZHEIMER'S DISEASE AMABIOTICS (FR) 2019-09-12 WO disclosed
US-20190224174-A1 COMPOUNDS FOR TREATING DISEASES ASSOCIATED WITH A MITOCHONDRIAL DYSFUNCTION AMABIOTICS (FR) 2019-07-25 US disclosed
WO-2018041919-A1 COMPOUNDS FOR TREATING DISEASES ASSOCIATED WITH A MITOCHONDRIAL DYSFONCTION AMABIOTICS (FR) 2018-03-08 WO disclosed
EP-3290039-A1 COMPOUNDS FOR TREATING DISEASES ASSOCIATED WITH A MITOCHONDRIAL DYSFONCTION Amabiotics (FR) 2018-03-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230040247-A1 COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES SNCA, HTT, PARK7 TYMS 4634/4885FOLR1 3238/4885SLC19A1 317/4885
US-20210046056-A1 Compounds for Treating Diseases Associated with a Mitochondrial Dysfunction NDUFAB1, FH, TFAM TYMS 3412/4885FOLR1 3377/4885SLC19A1 502/4885
US-20190224174-A1 COMPOUNDS FOR TREATING DISEASES ASSOCIATED WITH A MITOCHONDRIAL DYSFUNCTION NDUFAB1, FH, TFAM TYMS 3412/4885FOLR1 3377/4885SLC19A1 502/4885
US-10857135-B2 Compounds for treating diseases associated with a mitochondrial dysfunction NDUFAB1, FH, TFAM TYMS 3412/4885FOLR1 3377/4885SLC19A1 502/4885
US-20210052589-A1 COMPOUNDS FOR TREATING ALZHEIMER'S DISEASE PSEN1, PSEN2, MAPT TYMS 3657/4885FOLR1 1546/4885SLC19A1 378/4885
US-11684611-B2 Compounds for treating diseases associated with a mitochondrial dysfunction NDUFAB1, FH, TFAM TYMS 3412/4885FOLR1 3377/4885SLC19A1 502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.