Sugi Predict

Sugi Predict / Compounds / SCHEMBL19929829

SCHEMBL19929829

SCHEMBL19929829

O=C1c2c(O)cc(O)cc2-c2c(-c3ccccc3)oc3cc(O)cc1c23

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.64
▸ KMT2A Q03164 6/20 0.64
▸ HSP90AA1 P07900 1/20 0.64
▸ ABCB1 P08183 6/20 0.58
▸ CYP3A4 P08684 6/20 0.58
▸ MAPT P10636 6/20 0.58
▸ CYP2C9 P11712 4/20 0.58
▸ XDH P47989 4/20 0.58
▸ FTO Q9C0B1 4/20 0.58
▸ CA12 O43570 3/20 0.58
▸ CYP1A1 P04798 3/20 0.58
▸ CYP1A2 P05177 3/20 0.58
▸ CYP2D6 P10635 3/20 0.58
▸ CYP2C19 P33261 3/20 0.58
▸ PPARG P37231 3/20 0.58
▸ CA7 P43166 3/20 0.58
▸ CYP1B1 Q16678 3/20 0.58
▸ TRPC5 Q9UL62 3/20 0.58
▸ CYP19A1 P11511 2/20 0.58
▸ MAOA P21397 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29732709 0.91 CYP3A4 (0.57) MEN1KMT2AHSP90AA1ABCB1CYP3A4
SCHEMBL19929836 0.91 CYP3A4 (0.57) MEN1KMT2AHSP90AA1ABCB1CYP3A4
SCHEMBL19929846 0.87 LCK (0.49) MEN1KMT2AHSP90AA1ABCB1CYP3A4
SCHEMBL19929835 0.82 CYP3A4 (0.50) MEN1KMT2AHSP90AA1ABCB1CYP3A4
SCHEMBL19929831 0.80 MEN1 (0.51) MEN1KMT2AHSP90AA1ABCB1CYP3A4
SCHEMBL12940979 0.78 MEN1 (1.00) MEN1KMT2AHSP90AA1ABCB1CYP3A4
SCHEMBL19934851 0.76 KDM4E (0.51) MEN1KMT2AHSP90AA1ABCB1CYP3A4
SCHEMBL19929827 0.76 KDM4E (0.51) MEN1KMT2AHSP90AA1ABCB1CYP3A4
SCHEMBL19934850 0.75 CYP1A2 (0.47) MEN1KMT2AHSP90AA1ABCB1CYP3A4
SCHEMBL19934849 0.74 CYP3A4 (0.50) MEN1KMT2AHSP90AA1ABCB1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10508092-B2 Synthesis of novel analogs of diptoindonesin G, compounds formed thereby, and pharmaceutical compositions containing them WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2019-12-17 — — US disclosed
US-20180065945-A1 SYNTHESIS OF NOVEL ANALOGS OF DIPTOINDONESIN G, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY 2018-03-08 — — US disclosed
US-20180065945-A1 SYNTHESIS OF NOVEL ANALOGS OF DIPTOINDONESIN G, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY 2018-03-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180065945-A1 SYNTHESIS OF NOVEL ANALOGS OF DIPTOINDONESIN G, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM HPGDS, DPP7, DPEP1 MEN1 157/4885KMT2A 4047/4885HSP90AA1 4224/4885
US-10508092-B2 Synthesis of novel analogs of diptoindonesin G, compounds formed thereby, and pharmaceutical compositions containing them HPGDS, DPP7, DPEP1 MEN1 157/4885KMT2A 4047/4885HSP90AA1 4224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback