Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979844 | 0.97 | ALDH1A1 (0.43) | ALDH1A1KDM4ECYP3A4SLC6A2SLC6A4 | |
| SCHEMBL1993585 | 0.90 | GSR (0.39) | ALDH1A1KDM4ECYP3A4SLC6A2SLC6A4 | |
| SCHEMBL13271383 | 0.77 | GSR (0.41) | ALDH1A1KDM4ECYP3A4GSRRIPK1 | |
| SCHEMBL4443813 | 0.76 | KMT2A (0.47) | ALDH1A1KDM4ECYP3A4GSRHPGD | |
| SCHEMBL443077 | 0.74 | ALDH1A1 (0.69) | ALDH1A1KDM4ESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14376038 | 0.74 | ALDH1A1 (0.39) | ALDH1A1KDM4ECYP3A4GSRRIPK1 | |
| Nitric Acid SCHEMBL2006085 | 0.71 | ALDH1A1 (0.35) | ALDH1A1KDM4ELMNA | |
| Nitric Acid SCHEMBL1979549 | 0.71 | ALDH1A1 (0.35) | ALDH1A1KDM4ELMNA | |
| SCHEMBL11868344 | 0.69 | ALDH1A1 (0.49) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| Phenyl Ethanol SCHEMBL9453901 | 0.68 | LMNA (0.43) | ALDH1A1KDM4ECYP3A4GSRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348073-A1 | Use of diamino-alcohol compouds in high solids mineral slurries | Dow Global Technologies LLC (US) | 2011-07-27 | — | — | EP | disclosed |
| EP-2341093-A1 | Novel diamino-alcohol compounds, their manufacture and use in epoxy resins | Dow Global Technologies LLC (US) | 2011-07-06 | — | — | EP | disclosed |
| EP-2338872-A2 | Diamino-alcohol compounds and processes for their manufacture | Dow Global Technologies LLC (US) | 2011-06-29 | — | — | EP | disclosed |
| EP-2338941-A1 | Novel diamino-alcohol compounds, their manufacture and use in coatings applications | Dow Global Technologies LLC (US) | 2011-06-29 | — | — | EP | disclosed |
| US-20110147649-A1 | Novel diamino-alcohol compounds, their manufacture and use in high solids mineral slurries | ADVANCION CORPORATION | 2011-06-23 | — | — | US | disclosed |
| US-20110152574-A1 | Novel diamino-alcohol compounds and processes for their manufacture | ADVANCION CORPORATION | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152574-A1 | Novel diamino-alcohol compounds and processes for their manufacture | ADH1A, ADH1C, ADH5 | ALDH1A1 16/4885KDM4E 542/4885CYP3A4 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.