Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24378624 | 0.77 | CYP11B1 (0.45) | ESRRATLR8CYP11B1CYP11B2L3MBTL1 | |
| SCHEMBL19936632 | 0.73 | HSP90AA1 (0.45) | CRHR1 | |
| SCHEMBL3436659 | 0.72 | ACHE (0.40) | ESRRACRHR1MAPTTP53KDM4E | |
| SCHEMBL8270922 | 0.70 | FFAR1 (0.40) | RIPK1SMN1; SMN2 | |
| SCHEMBL19936484 | 0.70 | ALDH1A1 (0.37) | CRHR1MAPTLMNATP53KDM4E | |
| SCHEMBL3435957 | 0.69 | CA9 (0.55) | ESRRATLR8ALPLCA9MAPT | |
| SCHEMBL10049093 | 0.68 | CRHR1 (0.38) | TLR8ALPLCRHR1CA9MAPT | |
| SCHEMBL3448871 | 0.67 | KMT2A (0.42) | ESRRATLR8ALPLCRHR1CA9 | |
| SCHEMBL18436578 | 0.65 | RIPK1 (0.34) | RIPK1SMN1; SMN2KDM4E | |
| SCHEMBL32667294 | 0.65 | RIPK1 (0.34) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |