Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102004 | 0.84 | MAOA (0.41) | MAOAMAOBTSHRALDH1A1TP53 | |
| SCHEMBL23891572 | 0.80 | MEN1 (0.41) | MAPTHDAC8TSHRALDH1A1TP53 | |
| SCHEMBL7920797 | 0.79 | TSHR (0.39) | MAPTHDAC8TSHRALDH1A1TP53 | |
| SCHEMBL14632264 | 0.78 | MAPT (0.45) | MAPTHDAC8MAOAMAOBCA12 | |
| SCHEMBL11842763 | 0.77 | GABRA1 (0.45) | MAOAMAOBTSHRALDH1A1LMNA | |
| SCHEMBL2313481 | 0.76 | MAOA (0.58) | MAOAMAOBTSHRKMT2A | |
| SCHEMBL498531 | 0.76 | NPC1 (0.45) | MAPTTSHRALDH1A1LMNAMEN1 | |
| SCHEMBL25934708 | 0.75 | TSHR (0.35) | MAOAMAOBTSHR | |
| SCHEMBL25906211 | 0.75 | MAPT (0.50) | MAPTHDAC8MAOAMAOBALDH1A1 | |
| SCHEMBL11853872 | 0.74 | GABRA1 (0.43) | MAPTMAOAMAOBTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742635-B1 | SUBSTITUTED ORGANOSULFUR COMPOUNDS AND METHODS OF USING THEREOF | ACEA BIOSCIENCES INC (US) | 2018-03-07 | — | — | EP | disclosed |