Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11842763 | 0.86 | GABRA1 (0.45) | TSHRMAOAMAOBGABRA1GABRB2 | |
| SCHEMBL7102004 | 0.80 | MAOA (0.41) | TSHRMAOAMAOBCES2CES1 | |
| SCHEMBL25934704 | 0.77 | HPGD (0.33) | TSHRCES1 | |
| SCHEMBL27248328 | 0.75 | CES2 (0.46) | CES2CES1 | |
| SCHEMBL19940285 | 0.75 | MAPT (0.45) | TSHRMAOAMAOB | |
| SCHEMBL29056470 | 0.75 | ALDH1A1 (0.34) | PRMT5CES2CES1 | |
| SCHEMBL26617260 | 0.74 | TSHR (0.35) | TSHRPRMT5CES2CES1GABRA1 | |
| SCHEMBL498531 | 0.72 | NPC1 (0.45) | TSHR | |
| SCHEMBL2313481 | 0.72 | MAOA (0.58) | TSHRMAOAMAOB | |
| SCHEMBL24385024 | 0.71 | ALDH1A1 (0.48) | TSHRMAOAMAOBCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |