Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 11/20 | 0.57 |
| ▸ | CA1 | P00915 | 8/20 | 0.57 |
| ▸ | CA12 | O43570 | 6/20 | 0.57 |
| ▸ | CA2 | P00918 | 5/20 | 0.56 |
| ▸ | CA4 | P22748 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1618166 | 0.90 | ESR1 (0.61) | CA9CA1CA12CA2CA4 | |
| SCHEMBL1995596 | 0.85 | S100B (0.57) | MEN1KMT2AESR1NPSR1ALDH1A1 | |
| SCHEMBL17281691 | 0.84 | PTGES (0.61) | CA9CA1CA12CA2CA4 | |
| SCHEMBL9339007 | 0.82 | CA9 (0.77) | CA9CA1CA12CA2CA4 | |
| SCHEMBL4234750 | 0.81 | CA9 (0.77) | CA9CA1CA12CA2CA4 | |
| SCHEMBL15081236 | 0.80 | CA9 (0.51) | CA9CA1CA12CA2CA4 | |
| SCHEMBL15176768 | 0.80 | MAP4K4 (0.45) | CA9CA1CA12CA2CA4 | |
| SCHEMBL27464004 | 0.80 | POLB (0.47) | CA9CA1CA2CA4MEN1 | |
| SCHEMBL17946636 | 0.80 | MEN1 (0.59) | CA9CA1CA12CA2CA4 | |
| SCHEMBL14016924 | 0.79 | CA9 (0.64) | CA9CA1CA12CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338485-A1 | Substituted 1,3-dioxoisoindolines as medicine | Grünenthal GmbH (DE) | 2011-06-29 | — | — | EP | disclosed |
| US-5162489-A | Containing a 1,1,3-trimethylphenylindane moiety | AKZO N.V. (NL) | 1992-11-10 | — | — | US | disclosed |
| US-4980504-A | WHICH HAVE HIGH GLASS TRANSITION TEMPERATURES | AKZO N.V. (NL) | 1990-12-25 | — | — | US | disclosed |
| EP-0357106-A1 | Aromatic amide groups-containing diamines and polymers prepared therefrom | AKZO N.V. (NL) | 1990-03-07 | — | — | EP | disclosed |