Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19945803 | 0.89 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL19945798 | 0.88 | KCNQ3 (0.32) | LMNAALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL20343740 | 0.81 | SLC26A6 (0.37) | RAB9ASMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL19945665 | 0.81 | ABCB1 (0.38) | RAB9ASMN1; SMN2ALDH1A1KMT2AMAPT | |
| SCHEMBL20343735 | 0.77 | RAB9A (0.32) | RAB9ACRHR1 | |
| SCHEMBL20343818 | 0.77 | HPGD (0.39) | RAB9ALMNAALDH1A1KDM4EHPGD | |
| SCHEMBL21318994 | 0.74 | TLR7 (0.33) | RAB9ANPC1 | |
| SCHEMBL21319007 | 0.72 | RAB9A (0.31) | RAB9ASMN1; SMN2MAPT | |
| SCHEMBL19945582 | 0.71 | HTT (0.34) | RAB9ALMNAALDH1A1KDM4EHPGD | |
| SCHEMBL19945779 | 0.71 | MEN1 (0.36) | RAB9ASMN1; SMN2LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3865482-A1 | 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2021-08-18 | — | — | EP | disclosed |
| EP-3504210-B1 | 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2021-02-24 | — | — | EP | disclosed |
| WO-2018041763-A1 | 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-08 | — | — | WO | disclosed |