Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273218 | 0.89 | PDK1 (0.60) | PDK1PDK2PDK3PDK4RAB9A | |
| SCHEMBL8728009 | 0.83 | CYP17A1 (0.60) | PDK1PDK2PDK3PDK4RAB9A | |
| SCHEMBL25736767 | 0.77 | RAB9A (0.51) | PDK1PDK2PDK3PDK4RAB9A | |
| SCHEMBL4315966 | 0.77 | MEN1 (0.59) | RAB9ANPC1MAPTNAMPTMEN1 | |
| SCHEMBL25012380 | 0.77 | HPGD (0.61) | RAB9ANPC1MAPTNPSR1TSHR | |
| SCHEMBL7143564 | 0.77 | MEN1 (0.64) | PDK1PDK2PDK3PDK4RAB9A | |
| SCHEMBL2349306 | 0.76 | PDK1 (0.46) | PDK1PDK2PDK3PDK4RAB9A | |
| SCHEMBL10941324 | 0.76 | NAMPT (0.69) | RAB9ANPC1MAPTTSHRNAMPT | |
| SCHEMBL7477944 | 0.75 | KMT2A (0.66) | RAB9ANPC1MAPTNPSR1NAMPT | |
| SCHEMBL13055402 | 0.75 | CYP17A1 (0.59) | NAMPTSMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3486242-B1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2021-12-08 | — | — | EP | disclosed |
| US-11084808-B2 | Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-08-10 | — | — | US | disclosed |
| US-20200199115-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2020-06-25 | — | — | US | disclosed |
| US-10633375-B2 | Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof | Jinagsu Hengrui Medicine Co., Ltd (CN) | 2020-04-28 | — | — | US | disclosed |
| US-20190185464-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-06-20 | — | — | US | disclosed |
| EP-3486242-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2019-05-22 | — | — | EP | disclosed |
| WO-2018041122-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2018-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10633375-B2 | Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof | F11, F2, F7 | PDK1 876/4885PDK2 1186/4885PDK3 2286/4885 |
| US-20200199115-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | F11, F2, F7 | PDK1 697/4885PDK2 1149/4885PDK3 2461/4885 |
| US-20190185464-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | F11, F2, F7 | PDK1 876/4885PDK2 1186/4885PDK3 2286/4885 |
| US-11084808-B2 | Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof | F11, F2, F7 | PDK1 876/4885PDK2 1186/4885PDK3 2286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.