Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 12/20 | 0.33 |
| ▸ | MEN1 | O00255 | 11/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.33 |
| ▸ | HTT | P42858 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 9/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19458942 | 0.76 | MAPK1 (0.41) | RXRAMAPTMEN1KMT2AHTT | |
| SCHEMBL25368387 | 0.75 | ALOX15 (0.43) | RXRAMAPTMEN1KMT2AHTT | |
| SCHEMBL3819565 | 0.75 | RXRA (0.41) | RXRAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL30019983 | 0.75 | RXRA (0.41) | RXRAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL2723642 | 0.74 | EPHX2 (0.39) | MAPTALDH1A1L3MBTL1POLBGAA | |
| SCHEMBL14018146 | 0.73 | L3MBTL1 (0.39) | RXRAMAPTMEN1KMT2AHTT | |
| SCHEMBL19606074 | 0.73 | ALDH1A1 (0.44) | RXRAMAPTMEN1KMT2AHTT | |
| SCHEMBL31342255 | 0.73 | RXRA (0.35) | RXRAMBOAT4 | |
| SCHEMBL16899381 | 0.73 | MBOAT4 (0.39) | RXRAMAPTMEN1KMT2AHTT | |
| SCHEMBL17711299 | 0.73 | RXRA (0.35) | RXRAMBOAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510032-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | Incyte Corporation (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018049200-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |