Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | BAX | Q07812 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL27775292 | 0.83 | LTA4H (0.60) | LTA4HTSHRPARP10FFAR1ALOX15 | |
| Diphenylether SCHEMBL5918274 | 0.83 | FFAR1 (0.70) | LTA4HTSHRPARP10FFAR1ALOX15 | |
| Diphenylether SCHEMBL3353061 | 0.83 | LTA4H (0.60) | LTA4HTSHRPARP10FFAR1ALOX15 | |
| Diphenylether SCHEMBL10618785 | 0.82 | PARP10 (0.71) | LTA4HTSHRPARP10FFAR1SRD5A2 | |
| Diphenylether SCHEMBL8165466 | 0.82 | PARP10 (0.71) | LTA4HTSHRPARP10FFAR1SRD5A2 | |
| Anisole SCHEMBL27727512 | 0.82 | CA4 (0.61) | LTA4HPARP10ALOX15SMN1; SMN2 | |
| Diphenylether SCHEMBL360280 | 0.82 | LTA4H (0.75) | LTA4HTSHRPARP10FFAR1SRD5A2 | |
| Diphenylether SCHEMBL1965337 | 0.82 | LTA4H (0.75) | LTA4HTSHRPARP10FFAR1SRD5A2 | |
| Diphenylether SCHEMBL5606885 | 0.82 | LTA4H (0.75) | LTA4HTSHRPARP10FFAR1SRD5A2 | |
| SCHEMBL29070669 | 0.81 | PARP10 (0.53) | LTA4HTSHRPARP10FFAR1ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510113-B1 | ALKYD POLYMER COMPOSITIONS AND PRODUCT FORMULATIONS FORMED THEREFROM | ARKEMA INC (US) | 2021-09-22 | — | — | EP | claimed |
| US-20200181323-A1 | ALKYD POLYMER COMPOSITIONS AND PRODUCT FORMULATIONS FORMED THEREFROM | ARKEMA INC. | 2020-06-11 | — | — | US | claimed |
| EP-3510113-A1 | ALKYD POLYMER COMPOSITIONS AND PRODUCT FORMULATIONS FORMED THEREFROM | Arkema Inc. (US) | 2019-07-17 | — | — | EP | claimed |
| WO-2018048638-A1 | ALKYD POLYMER COMPOSITIONS AND PRODUCT FORMULATIONS FORMED THEREFROM | ARKEMA INC. (US) | 2018-03-15 | — | — | WO | claimed |
| US-11814477-B2 | Alkyd polymer compositions and product formulations formed therefrom | ARKEMA INC. (US) | 2023-11-14 | — | — | US | disclosed |
| EP-3510113-B1 | ALKYD POLYMER COMPOSITIONS AND PRODUCT FORMULATIONS FORMED THEREFROM | ARKEMA INC (US) | 2021-09-22 | — | — | EP | disclosed |
| US-20200181323-A1 | ALKYD POLYMER COMPOSITIONS AND PRODUCT FORMULATIONS FORMED THEREFROM | ARKEMA INC. | 2020-06-11 | — | — | US | disclosed |
| EP-3510113-A1 | ALKYD POLYMER COMPOSITIONS AND PRODUCT FORMULATIONS FORMED THEREFROM | Arkema Inc. (US) | 2019-07-17 | — | — | EP | disclosed |
| CN-109642108-A | Alkyd polymer composition and the product formulation formed by it | 阿科玛股份有限公司 | 2019-04-16 | — | — | CN | disclosed |
| WO-2018048638-A1 | ALKYD POLYMER COMPOSITIONS AND PRODUCT FORMULATIONS FORMED THEREFROM | ARKEMA INC. (US) | 2018-03-15 | — | — | WO | disclosed |