Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 8/20 | 0.63 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
| ▸ | MMP14 | P50281 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19964478 | 0.78 | LOXL2 (1.00) | LOXL2CYP11B1CYP11B2 | |
| Trifluoroacetic Acid SCHEMBL19953228 | 0.75 | LOXL2 (0.82) | LOXL2CYP11B1CYP11B2MMP2MMP13 | |
| SCHEMBL19953229 | 0.75 | LOXL2 (0.60) | LOXL2CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL3715051 | 0.74 | ATM (0.69) | CYP11B1CYP11B2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL1179546 | 0.73 | CYP11B1 (0.76) | CYP11B1CYP11B2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL1179945 | 0.73 | CYP11B2 (1.00) | CYP11B1CYP11B2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL19953274 | 0.71 | LOXL2 (0.65) | LOXL2CYP11B1CYP11B2CYP19A1MMP2 | |
| SCHEMBL19964757 | 0.71 | LOXL2 (1.00) | LOXL2CYP2A6 | |
| SCHEMBL641533 | 0.71 | CYP11B2 (0.64) | CYP11B1CYP11B2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL641553 | 0.71 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP1A2CYP3A4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | claimed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |