Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | GRK2 | P25098 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1869252 | 0.86 | ALDH1A1 (0.49) | FLT3SMN1; SMN2ALDH1A1MMP13 | |
| SCHEMBL19964496 | 0.84 | IDO1 (0.48) | IDO1GRK2FLT3SLC2A1FAAH | |
| SCHEMBL19964494 | 0.83 | FLT3 (0.46) | IDO1GRK2FLT3SLC2A1FAAH | |
| SCHEMBL19964310 | 0.83 | LOXL2 (0.53) | IDO1GRK2FLT3SLC2A1FAAH | |
| SCHEMBL19964536 | 0.78 | FLT3 (0.42) | IDO1GRK2FLT3SLC2A1FAAH | |
| SCHEMBL2945788 | 0.75 | MMP13 (0.48) | IDO1FLT3SMN1; SMN2ALDH1A1MMP13 | |
| SCHEMBL13085846 | 0.75 | IDO1 (0.64) | IDO1ALDH1A1 | |
| SCHEMBL1867752 | 0.73 | CYP11B1 (0.55) | FLT3SMN1; SMN2ALDH1A1MMP13 | |
| SCHEMBL30202437 | 0.72 | BRD4 (0.59) | IDO1FLT3SMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL17807884 | 0.72 | BRD4 (0.59) | IDO1FLT3SMN1; SMN2ALDH1A1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |