Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 11/20 | 0.73 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19964313 | 0.85 | LOXL2 (1.00) | LOXL2CHEK2 | |
| Hydrochloric Acid SCHEMBL19953384 | 0.84 | LOXL2 (0.98) | LOXL2 | |
| SCHEMBL19964757 | 0.83 | LOXL2 (1.00) | LOXL2 | |
| SCHEMBL19953219 | 0.76 | LOXL2 (0.60) | LOXL2 | |
| SCHEMBL19953274 | 0.73 | LOXL2 (0.65) | LOXL2 | |
| SCHEMBL400512 | 0.68 | LOXL2 (0.62) | LOXL2 | |
| SCHEMBL19953414 | 0.68 | LOXL2 (0.57) | LOXL2 | |
| SCHEMBL6160873 | 0.67 | LOXL2 (0.58) | LOXL2LTA4HACACBLOX | |
| SCHEMBL19964478 | 0.67 | LOXL2 (1.00) | LOXL2 | |
| SCHEMBL19953383 | 0.67 | LOXL2 (0.56) | LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | claimed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |