Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 9/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19954808 | 0.99 | LOXL2 (0.55) | LOXL2PRMT5WDR77PRKCZCYP11B1 | |
| SCHEMBL7293410 | 0.76 | CYP11B1 (0.54) | PRMT5WDR77PRKCZCYP11B1CYP11B2 | |
| SCHEMBL17998728 | 0.75 | PRKCZ (0.54) | PRMT5WDR77PRKCZCYP11B1CYP11B2 | |
| SCHEMBL21264421 | 0.74 | TRPA1 (0.58) | PRKCZCYP11B1CYP11B2CYP2D6CYP2C9 | |
| SCHEMBL29501876 | 0.74 | CYP11B1 (0.74) | PRMT5WDR77PRKCZCYP11B1CYP11B2 | |
| SCHEMBL19953219 | 0.74 | LOXL2 (0.60) | LOXL2PRMT5WDR77DYRK1A | |
| SCHEMBL19953274 | 0.73 | LOXL2 (0.65) | LOXL2CYP11B1CYP11B2CYP2D6CYP2C9 | |
| SCHEMBL1871920 | 0.73 | CYP11B1 (0.53) | PRMT5WDR77PRKCZCYP11B1CYP11B2 | |
| SCHEMBL26103671 | 0.72 | CYP11B1 (0.55) | PRMT5WDR77PRKCZCYP11B1CYP11B2 | |
| SCHEMBL19964478 | 0.72 | LOXL2 (1.00) | LOXL2PRMT5WDR77CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | claimed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |