Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | GRM7 | Q14831 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953631 | 0.79 | HDAC4 (0.41) | HDAC4HDAC7HDAC5XIAPTSHR | |
| SCHEMBL19953512 | 0.73 | UBE2M (0.43) | FABP5GRM7HRH3MTNR1AMTNR1B | |
| SCHEMBL19953636 | 0.71 | FABP5 (0.44) | FABP5GRM7HRH3MTNR1AMTNR1B | |
| SCHEMBL19960879 | 0.71 | MEN1 (0.42) | FABP5GRM7HRH3MTNR1AMTNR1B | |
| SCHEMBL19953584 | 0.70 | FABP5 (0.43) | FABP5GRM7HRH3MTNR1AMTNR1B | |
| SCHEMBL19953485 | 0.70 | KCNQ2 (0.44) | FABP5GRM7HRH3MTNR1AMTNR1B | |
| SCHEMBL19953489 | 0.70 | FABP5 (0.43) | FABP5GRM7HRH3MTNR1AMTNR1B | |
| SCHEMBL19953533 | 0.70 | FABP5 (0.43) | FABP5GRM7HRH3MTNR1AMTNR1B | |
| SCHEMBL4486212 | 0.70 | ACE (0.45) | — | |
| SCHEMBL22861976 | 0.69 | BRD4 (0.45) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | claimed |
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |