Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953669 | 0.82 | MEN1 (0.42) | ALDH1A1KDM4ENOTUMLMNAAPOBEC3A | |
| SCHEMBL19953657 | 0.78 | PKM (0.47) | ALDH1A1CYP4F2CYP4A11TBXAS1 | |
| SCHEMBL19960636 | 0.69 | HDAC4 (0.43) | NOTUMGRM7 | |
| SCHEMBL20166097 | 0.67 | GRM7 (0.39) | ALDH1A1KDM4ENOTUMLMNAGRM7 | |
| SCHEMBL19960628 | 0.67 | PKM (0.48) | ALDH1A1CYP4F2CYP4A11TBXAS1 | |
| SCHEMBL20113096 | 0.67 | GRM7 (0.55) | ALDH1A1KDM4EGRM7MAPT | |
| SCHEMBL4028087 | 0.66 | TSHR (0.49) | ALDH1A1KDM4ECYP4F2CYP4A11LMNA | |
| SCHEMBL19953652 | 0.65 | ACE (0.47) | ACENOTUMGRM7 | |
| SCHEMBL11273360 | 0.65 | PIN1 (0.41) | CYP4F2CYP4A11LMNA | |
| SCHEMBL19953522 | 0.65 | ACE (0.47) | ACENOTUMGRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |