Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405501 | 0.88 | ALDH1A1 (0.40) | ALDH1A1GLATSHRHTTATM | |
| SCHEMBL3409297 | 0.80 | POLB (0.41) | TRPM8ALDH1A1HTTKDM4EMEN1 | |
| SCHEMBL19975122 | 0.72 | ALDH1A1 (0.40) | TRPM8ALDH1A1GLATSHRATM | |
| SCHEMBL26327651 | 0.71 | LMNA (0.44) | ALDH1A1GLATSHRHTTOPRD1 | |
| SCHEMBL3408229 | 0.69 | MDM2 (0.39) | ALDH1A1HTTOPRD1OPRM1MEN1 | |
| SCHEMBL15922647 | 0.69 | KDM4E (0.41) | ALDH1A1KDM4EMEN1NPC1MITF | |
| SCHEMBL6550464 | 0.67 | ALDH1A1 (0.44) | ALDH1A1GLATSHRHTTMEN1 | |
| SCHEMBL27171227 | 0.67 | MEN1 (0.50) | TRPM8ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL17161709 | 0.67 | NPC1 (0.46) | ALDH1A1TSHRATMKDM4EMEN1 | |
| SCHEMBL27171232 | 0.67 | MEN1 (0.50) | TRPM8ALDH1A1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3716963-A1 | ENHANCING T-CELL FUNCTION AND TREATING A T-CELL DYSFUNCTIONAL DISORDER WITH A COMBINATION OF AN LSD INHIBITOR AND A PD1 BINDING ANTAGONIST | Epiaxis Therapeutics Pty Ltd (AU) | 2020-10-07 | — | — | EP | disclosed |
| EP-3509627-A1 | LYSINE SPECIFIC HISTONE DEMETHYLASE-1 INHIBITORS AND USES THEREFOR | University of Canberra (AU) | 2019-07-17 | — | — | EP | disclosed |
| CN-107849611-A | biomarkers related to L SD1 inhibitors and uses thereof | 奥瑞泽恩基因组学股份有限公司 | 2018-03-27 | — | — | CN | disclosed |
| WO-2018045422-A1 | LYSINE SPECIFIC HISTONE DEMETHYLASE-1 INHIBITORS AND USES THEREFOR | UNIVERSITY OF CANBERRA (AU) | 2018-03-15 | — | — | WO | disclosed |