SCHEMBL1995431

SCHEMBL1995431

CC(C)(C)OC(=O)N1CCN(c2ccc(N)nn2)CC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 1/20 0.58
GPR119 Q8TDV5 7/20 0.54
CKS1B P61024 2/20 0.51
SKP1 P63208 2/20 0.51
SKP2 Q13309 2/20 0.51
SMARCA2 P51531 1/20 0.51
SMARCA4 P51532 1/20 0.51
PBRM1 Q86U86 1/20 0.51
ALDH1A1 P00352 1/20 0.48
LMNA P02545 1/20 0.48
MAPT P10636 1/20 0.48
ADK P55263 1/20 0.46
DDB1 Q16531 1/20 0.45
CRBN Q96SW2 1/20 0.45
PTPN11 Q06124 1/20 0.45
RET P07949 1/20 0.44
POLB P06746 1/20 0.43
HTT P42858 1/20 0.43
ATM Q13315 1/20 0.43
KIT P10721 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30778278 1.00 MAP4K4 (0.58) MAP4K4GPR119CKS1BSKP1SKP2
SCHEMBL18291258 0.95 CKS1B (0.54) MAP4K4GPR119CKS1BSKP1SKP2
SCHEMBL29793368 0.85 GPR119 (0.55) MAP4K4GPR119CKS1BSKP1SKP2
SCHEMBL20306398 0.85 GPR119 (0.55) MAP4K4GPR119CKS1BSKP1SKP2
SCHEMBL31271932 0.84 GPR119 (0.54) MAP4K4GPR119CKS1BSKP1SKP2
SCHEMBL1433407 0.84 TRPV1 (0.57) MAP4K4GPR119CKS1BSKP1SKP2
SCHEMBL30778281 0.84 TRPV1 (0.57) MAP4K4GPR119CKS1BSKP1SKP2
SCHEMBL18937654 0.84 GPR119 (0.63) MAP4K4GPR119CKS1BSKP1SKP2
SCHEMBL16427561 0.84 GPR119 (0.57) MAP4K4GPR119CKS1BSKP1SKP2
SCHEMBL25418306 0.83 PDE10A (0.48) MAP4K4GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146042-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2026-05-28 US disclosed
EP-4745138-A1 THIO-GLUTARIMIDO ISOINDOLINONE DERIVATIVE, BIFUNCTIONAL PROTEIN DEGRADER CONTAINING SAME, AND USES THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-05-20 EP disclosed
EP-4678638-A1 NEW E3 UBIQUITIN LIGASE LIGAND, PROTEIN DEGRADATION AGENT AND USE THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-01-14 EP disclosed
US-12521440-B2 Degradation of bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use BEONE MEDICINES I GMBH (CH) 2026-01-13 US disclosed
US-20250205345-A1 DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BEIGENE SWITZERLAND GMBH (CH) 2025-06-26 US disclosed
US-20250082762-A1 NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-03-13 US disclosed
US-20250073341-A1 BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-03-06 US disclosed
US-20250066389-A1 HETEROCYCLIC AMIDES AND METHODS OF USING THE SAME RGENTA THERAPEUTICS, INC. 2025-02-27 US disclosed
US-12161722-B2 Bifunctional heterocyclic compound having BTK degradation function via ubiquitin proteasome pathway, and use thereof KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2024-12-10 US disclosed
WO-2024245443-A1 COMPOUND BASED ON OXOISOINDOLINYL SUBSTITUTED TETRAHYDRO-2-PYRIMIDONE, AND USE THEREOF 标新生物医药科技(上海)有限公司 2024-12-05 WO disclosed
CN-103038233-A Pyridone and azapyridone compounds and methods of use GILEAD CONNECTICUT INC 2013-04-10 CN disclosed
US-8415355-B2 Pyrrolopyrimidine compounds and their uses NOVARTIS AG (CH) 2013-04-09 US disclosed
US-20120010191-A1 PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2012-01-12 US disclosed
US-20120010191-A1 PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2012-01-12 US disclosed
WO-2011140488-A1 PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE GILEAD CONNECTICUT, INC. (US) 2011-11-10 WO disclosed
US-20110152244-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2011-06-23 US disclosed
EP-2331547-A1 PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS Novartis AG (CH) 2011-06-15 EP disclosed
WO-2010070237-A1 DERIVATIVES OF 6-CYCLOAMINO-2-THIENYL-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE AND 6-CYCLOAMINO-2-FURANYL-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE, PREPARATION AND THERAPEUTIC APPLICATION THEREOF SANOFI-AVENTIS (FR) 2010-06-24 WO disclosed
US-20100105653-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG 2010-04-29 US disclosed
WO-2010020675-A1 PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS NOVARTIS AG (CH) 2010-02-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250073341-A1 BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF BTK, XIAP, SYK MAP4K4 1388/4885GPR119 4380/4885CKS1B 784/4885
US-20260146042-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK9, CDK6, CDK7 MAP4K4 119/4885GPR119 3309/4885CKS1B 38/4885
US-20110152244-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK6, CDK8, CDK7 MAP4K4 88/4885GPR119 3780/4885CKS1B 49/4885
US-20250082762-A1 NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF BTK, XIAP, UBE3C MAP4K4 1273/4885GPR119 4229/4885CKS1B 684/4885
US-20250066389-A1 HETEROCYCLIC AMIDES AND METHODS OF USING THE SAME SNRPA, SF3B5, RBM17 MAP4K4 3122/4885GPR119 1042/4885CKS1B 1090/4885
US-12161722-B2 Bifunctional heterocyclic compound having BTK degradation function via ubiquitin proteasome pathway, and use thereof BTK, XIAP, SYK MAP4K4 1388/4885GPR119 4380/4885CKS1B 784/4885
US-20120010191-A1 PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE PDXK, BTK, LCK MAP4K4 98/4885GPR119 2359/4885CKS1B 317/4885
US-20250205345-A1 DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BTK, CBL, LYN MAP4K4 1247/4885GPR119 4296/4885CKS1B 597/4885
US-20100105653-A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES CDK6, CDK8, CDK7 MAP4K4 88/4885GPR119 3780/4885CKS1B 49/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.