Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19964499 | 0.87 | HDAC1 (0.46) | HDAC1MEN1KMT2AKDM4A | |
| SCHEMBL19964300 | 0.87 | SYK (0.41) | HDAC1MEN1KMT2ALMNAKDM4A | |
| SCHEMBL19964492 | 0.85 | PTGES (0.40) | HDAC1MEN1KMT2AKDM4A | |
| SCHEMBL19249247 | 0.85 | MMP13 (0.47) | DYRK1AMMP13MTNR1AMEN1KMT2A | |
| SCHEMBL19964512 | 0.83 | GABRA1 (0.39) | HDAC1MEN1KMT2AKDM4A | |
| SCHEMBL19964507 | 0.79 | CA1 (0.37) | HDAC1MEN1KMT2ASCDKDM4A | |
| SCHEMBL3805722 | 0.79 | MTNR1A (0.51) | HDAC1MTNR1AMEN1KMT2AMTNR1B | |
| SCHEMBL19248874 | 0.76 | EGLN2 (0.42) | MMP13HDAC1MEN1KMT2APLA2G2A | |
| SCHEMBL20729415 | 0.76 | BCHE (0.43) | DYRK1AMMP13HDAC1MEN1KMT2A | |
| SCHEMBL23491567 | 0.76 | HDAC1 (0.41) | DYRK1AMMP13HDAC1MTNR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |