Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19964786 | 0.78 | PDE10A (0.54) | LOXL2LTA4HPDE10AKCNN1KCNN2 | |
| SCHEMBL30904901 | 0.75 | KDM4E (0.44) | SMN1; SMN2MEN1KMT2AGLAPOLB | |
| SCHEMBL17787543 | 0.71 | CHEK1 (0.43) | KDM4EMAPTCSNK1A1PDE10AGAA | |
| SCHEMBL7833635 | 0.70 | LOXL2 (0.48) | LOXL2MAPTL3MBTL1LTA4HCYP1A2 | |
| SCHEMBL7835390 | 0.70 | LOXL2 (0.51) | MEN1KMT2ALOXL2LTA4HPDE10A | |
| SCHEMBL31091400 | 0.68 | ALDH1A1 (0.40) | SMN1; SMN2MEN1KMT2APOLBHPGD | |
| SCHEMBL2177472 | 0.65 | DYRK1A (0.44) | MAPTCYP1A2CYP2C19PDE10AGAA | |
| SCHEMBL1680654 | 0.64 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AGLAPOLB | |
| SCHEMBL19697639 | 0.64 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2AGLAPOLB | |
| SCHEMBL30938605 | 0.64 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2AGLAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |