Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | VHL | P40337 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15000477 | 0.83 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM | |
| SCHEMBL19232076 | 0.83 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM | |
| SCHEMBL17833337 | 0.78 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM | |
| SCHEMBL19965701 | 0.78 | LMNA (0.52) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM | |
| SCHEMBL1896996 | 0.77 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM | |
| SCHEMBL1430802 | 0.75 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM | |
| SCHEMBL12630133 | 0.74 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM | |
| SCHEMBL19987400 | 0.74 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM | |
| SCHEMBL11775192 | 0.74 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM | |
| SCHEMBL6431541 | 0.73 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2ADORA2BGLAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399933-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180072660-A1 | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | BRISTOL MYERS SQUIBB CO (US) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072660-A1 | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | IDO1, IDO2, INMT | ALDH1A1 263/4885SMN1; SMN2 4521/4885ADORA2B 1196/4885 |
| US-10399933-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | IDO1, IDO2, INMT | ALDH1A1 263/4885SMN1; SMN2 4521/4885ADORA2B 1196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.