Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170535 | 0.88 | PKM (0.36) | NOTUM | |
| SCHEMBL20170522 | 0.88 | PKM (0.36) | NOTUM | |
| SCHEMBL20170529 | 0.78 | NOTUM (0.39) | NOTUM | |
| SCHEMBL20170530 | 0.70 | VSIR (0.34) | NOTUMMAPTL3MBTL1 | |
| SCHEMBL19969084 | 0.70 | ALDH1A1 (0.56) | NOTUMMAPTL3MBTL1 | |
| SCHEMBL3825307 | 0.70 | NOTUM (0.41) | NOTUMHDAC8 | |
| SCHEMBL19969069 | 0.68 | VSIR (0.33) | NOTUMGABRR1LMNA | |
| SCHEMBL18078731 | 0.65 | GAA (0.51) | NOTUMMAPTL3MBTL1HDAC8LMNA | |
| SCHEMBL13550164 | 0.64 | S1PR1 (0.33) | LMNACTSA | |
| SCHEMBL3822232 | 0.62 | NOTUM (0.37) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047139-A1 | COMPOUNDS AS MODULATORS OF TIGIT SIGNALLING PATHWAY | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-03-15 | — | — | WO | disclosed |