Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18522436 | 0.84 | GRM2 (0.36) | KCNMA1GRM2SLC9A1TDP1TSHR | |
| SCHEMBL25873809 | 0.81 | KCNMA1 (0.50) | KCNMA1SLC9A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL20821949 | 0.80 | KCNMA1 (0.43) | KCNMA1GRM2SLC9A1TDP1TSHR | |
| SCHEMBL23694613 | 0.78 | KCNMA1 (0.47) | KCNMA1SLC9A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL19829473 | 0.76 | SLC9A1 (0.50) | KCNMA1GRM2SLC9A1TDP1TSHR | |
| SCHEMBL14610056 | 0.76 | KCNMA1 (0.54) | KCNMA1SLC9A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL21371242 | 0.76 | KCNMA1 (0.42) | KCNMA1GRM2SLC9A1TDP1TSHR | |
| SCHEMBL23134778 | 0.74 | SLC9A1 (0.45) | KCNMA1SLC9A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL18994950 | 0.72 | LMNA (0.44) | LMNA | |
| SCHEMBL25873798 | 0.72 | KCNMA1 (0.50) | KCNMA1SLC9A1TSHRSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049152-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |