SCHEMBL19972058

SCHEMBL19972058

Nc1cccc(C(=O)Cl)c1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.48
MMP2 P08253 1/20 0.45
ALDH1A1 P00352 8/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 2/20 0.42
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41
KDM4E B2RXH2 3/20 0.41
KMT2A Q03164 2/20 0.41
FADS1 O60427 1/20 0.40
HSD17B10 Q99714 2/20 0.39
CYP3A4 P08684 1/20 0.39
CFTR P13569 1/20 0.39
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
RECQL P46063 1/20 0.38
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27321540 0.85 P2RX7 (0.39) P2RX7MMP2ALDH1A1ALOX15TSHR
SCHEMBL5285030 0.84 ALDH1A1 (0.52) P2RX7ALDH1A1ALOX15TSHRKDM4E
SCHEMBL14661611 0.83 MMP2 (0.45) P2RX7MMP2ALDH1A1TSHRGAA
SCHEMBL177101 0.83 TSHR (0.63) P2RX7MMP2ALDH1A1ALOX15TSHR
Hydrochloric Acid SCHEMBL11176877 0.81 TSHR (0.61) P2RX7MMP2ALDH1A1ALOX15TSHR
SCHEMBL5363326 0.81 MMP2 (0.44) P2RX7MMP2ALDH1A1TSHRGAA
SCHEMBL27459872 0.80 ALDH1A1 (0.39) P2RX7ALDH1A1ALOX15TSHRMAPT
SCHEMBL2473273 0.80 MMP2 (0.47) P2RX7MMP2ALDH1A1ALOX15TSHR
SCHEMBL3939921 0.79 MAPT (0.56) MMP2ALDH1A1ALOX15TSHRGAA
SCHEMBL30754399 0.79 MAPT (0.56) MMP2ALDH1A1ALOX15TSHRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106917077-B Electroless copper plating solution and electroless copper plating method for increasing hardness of copper plating layer 钧泽科技有限公司 2019-09-27 CN disclosed
US-9957241-B2 Aromatic diamine, an intermediate therefor, a method for producing the aromatic diamine, and a method for producing the intermediate therefor SEIKA CORPORATION (JP) 2018-05-01 US disclosed
US-20180079732-A1 AROMATIC DIAMINE, AN INTERMEDIATE THEREFOR, A METHOD FOR PRODUCING THE AROMATIC DIAMINE, AND A METHOD FOR PRODUCING THE INTERMEDIATE THEREFOR SEIKA CORPORATION (JP) 2018-03-22 US disclosed
CN-107531652-A Aromatic diamine, intermediate thereof, and processes for producing these 精化株式会社 2018-01-02 CN disclosed
CN-107034454-A Electroless copper plating solution and electroless copper plating method for improving copper plating smoothness 钧泽科技有限公司 2017-08-11 CN disclosed
CN-106917077-A Electroless copper plating solution and electroless copper plating method for increasing hardness of copper plating layer 钧泽科技有限公司 2017-07-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180079732-A1 AROMATIC DIAMINE, AN INTERMEDIATE THEREFOR, A METHOD FOR PRODUCING THE AROMATIC DIAMINE, AND A METHOD FOR PRODUCING THE INTERMEDIATE THEREFOR WEE1, WEE2, WASF2 P2RX7 1519/4885MMP2 4229/4885ALDH1A1 544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.