Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.47 |
| ▸ | HRAS | P01112 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6387864 | 0.82 | ROCK2 (0.44) | CTSLCTSS | |
| SCHEMBL20425199 | 0.81 | NR4A1 (0.53) | FFAR1ALOX5MAOBNR4A1NR4A2 | |
| SCHEMBL9537619 | 0.78 | GSK3B (0.49) | ALOX5MAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL10772200 | 0.77 | FFAR1 (0.59) | FFAR1 | |
| SCHEMBL3499841 | 0.75 | CTSC (0.59) | FFAR1MAOBCTSLCTSS | |
| SCHEMBL30771219 | 0.75 | LTA4H (0.54) | FFAR1ALOX5MAOBNR4A1NR4A2 | |
| SCHEMBL6386461 | 0.75 | MAOB (0.57) | FFAR1MAOB | |
| SCHEMBL3657890 | 0.75 | ESR1 (0.37) | CTSLCTSS | |
| SCHEMBL12494760 | 0.75 | CTSK (0.47) | CTSLCTSS | |
| SCHEMBL20425137 | 0.75 | PPARG (0.59) | FFAR1MAOBNR4A1NR4A2NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512839-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center And Research Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |