SCHEMBL19974714

SCHEMBL19974714

CC(C(O)C(=O)NCc1cccc(Cl)c1)N(C=O)CC(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MASP2 O00187 1/20 0.43
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
RXFP1 Q9HBX9 1/20 0.40
CFD P00746 1/20 0.40
SLC2A1 P11166 1/20 0.39
EPHX2 P34913 1/20 0.39
OPRM1 P35372 1/20 0.39
OPRL1 P41146 1/20 0.39
APEX1 P27695 1/20 0.38
ADAM17 P78536 1/20 0.38
P2RX7 Q99572 1/20 0.38
KMT2A Q03164 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19975564 0.86 MASP2 (0.48) MASP2ALDH1A1LMNARXFP1SLC2A1
SCHEMBL19974811 0.83 MASP2 (0.47) MASP2ALDH1A1LMNARXFP1SLC2A1
SCHEMBL19975522 0.83 GABRP (0.41) MASP2RXFP1CFDSLC2A1OPRM1
SCHEMBL19975435 0.82 MASP2 (0.46) MASP2ALDH1A1LMNARXFP1SLC2A1
SCHEMBL19975379 0.81 ALDH1A1 (0.51) MASP2ALDH1A1RXFP1EPHX2ADAM17
SCHEMBL19975405 0.81 MASP2 (0.49) MASP2ALDH1A1LMNARXFP1APEX1
SCHEMBL19975248 0.79 ALDH1A1 (0.41) MASP2ALDH1A1RXFP1ADAM17P2RX7
SCHEMBL19974965 0.78 MASP2 (0.50) MASP2ALDH1A1LMNARXFP1SLC2A1
SCHEMBL19974737 0.77 MASP2 (0.44) MASP2ALDH1A1LMNARXFP1SLC2A1
SCHEMBL19975237 0.76 MASP2 (0.53) MASP2ALDH1A1LMNARXFP1SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220356148-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2022-11-10 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
CN-110062753-A Antiviral compounds 哈普洛根有限责任公司 2019-07-26 CN disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
EP-3512836-A1 ANTIVIRAL COMPOUNDS Haplogen GmbH (AT) 2019-07-24 EP disclosed
WO-2018050631-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225575-A1 ANTIVIRAL COMPOUNDS PLA2G1B, PLA2G12A, PLA2G4C MASP2 1122/4885ALDH1A1 2271/4885LMNA 1909/4885
US-20220356148-A1 ANTIVIRAL COMPOUNDS PLA2G12A, PLA2G1B, PLA2G4C MASP2 862/4885ALDH1A1 2673/4885LMNA 2058/4885
US-11091428-B2 Antiviral compounds PLA2G1B, PLA2G12A, PLA2G4C MASP2 1122/4885ALDH1A1 2271/4885LMNA 1909/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.