Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 9/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.37 |
| ▸ | TEK | Q02763 | 3/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | FLT4 | P35916 | 6/20 | 0.35 |
| ▸ | FLT3 | P36888 | 6/20 | 0.35 |
| ▸ | CSF1R | P07333 | 5/20 | 0.35 |
| ▸ | KIT | P10721 | 5/20 | 0.35 |
| ▸ | LYN | P07948 | 4/20 | 0.35 |
| ▸ | SRC | P12931 | 4/20 | 0.35 |
| ▸ | FLT1 | P17948 | 4/20 | 0.35 |
| ▸ | BLK | P51451 | 4/20 | 0.35 |
| ▸ | PLK4 | O00444 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.35 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976802 | 0.87 | KDR (0.36) | ABL1BCRKDRFLT4FLT3 | |
| SCHEMBL19976730 | 0.87 | HDAC6 (0.41) | MAPK10MAPK8FLT4PLK4CDK1 | |
| SCHEMBL16752857 | 0.84 | CHRNA1 (0.34) | JAK2CDK2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL16752855 | 0.84 | CHRNA1 (0.34) | JAK2CDK2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL19976801 | 0.84 | TRPA1 (0.37) | ABL1BCRMAPK8FLT4PLK4 | |
| SCHEMBL19976766 | 0.84 | ABL1 (0.43) | ABL1BCRKDREPHB4TEK | |
| SCHEMBL19976849 | 0.83 | HDAC6 (0.36) | ABL1BCRKDRFLT4FLT3 | |
| SCHEMBL19976765 | 0.82 | NTRK1 (0.41) | MAPK8FLT4FLT3PLK4CDK1 | |
| SCHEMBL16752859 | 0.82 | MEN1 (0.37) | KDRFLT3KITFGFR1FGFR2 | |
| SCHEMBL16752861 | 0.82 | MEN1 (0.37) | KDRFLT3KITFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |