Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | BCR | P11274 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.36 |
| ▸ | TEK | Q02763 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.35 |
| ▸ | FLT4 | P35916 | 4/20 | 0.35 |
| ▸ | PLK4 | O00444 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.35 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976846 | 0.88 | KDM4E (0.42) | ABL1BCRMAPK8MAPK10DYRK1A | |
| SCHEMBL19976926 | 0.85 | GRM4 (0.48) | DYRK1A | |
| SCHEMBL19976780 | 0.85 | LMNA (0.33) | ABL1BCRDYRK1AMAPK1LMNA | |
| SCHEMBL19976857 | 0.85 | MAPK1 (0.35) | ABL1BCRMAPK8DYRK1AMAPK1 | |
| SCHEMBL19976758 | 0.84 | DYRK1A (0.40) | ABL1BCRKDRDYRK1AMAPK1 | |
| SCHEMBL19976726 | 0.84 | ABL1 (0.41) | ABL1BCRCTSKMAPK8MAPK10 | |
| SCHEMBL19976866 | 0.83 | DYRK1A (0.42) | MAPK8DYRK1AMAPK1AURKBFLT4 | |
| SCHEMBL19976776 | 0.83 | GSK3B (0.48) | DYRK1AMAPK1GSK3BHDAC6 | |
| SCHEMBL19976789 | 0.82 | GSK3B (0.42) | DYRK1AMAPK1LMNACDK1CDK2 | |
| SCHEMBL19976767 | 0.80 | GSK3B (0.51) | MAPK8MAPK10MAPK1LMNAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |