Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | PAK4 | O96013 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976866 | 0.90 | DYRK1A (0.42) | DYRK1AMAPK8MAPK1GSK3BPAK4 | |
| SCHEMBL19976776 | 0.89 | GSK3B (0.48) | HDAC6DYRK1AMAPK1GSK3B | |
| SCHEMBL19976857 | 0.88 | MAPK1 (0.35) | KDM4EHDAC6DYRK1AABL1BCR | |
| SCHEMBL19976766 | 0.88 | ABL1 (0.43) | KDM4EALDH1A1HDAC6DYRK1AABL1 | |
| SCHEMBL19976757 | 0.87 | HDAC6 (0.39) | HDAC6DYRK1AABL1BCRMAPK10 | |
| SCHEMBL19976767 | 0.87 | GSK3B (0.51) | HDAC6MAPK10MAPK8MAPK1GSK3B | |
| SCHEMBL19976854 | 0.87 | GSK3B (0.42) | HDAC6DYRK1AMAPK10MAPK8MAPK1 | |
| SCHEMBL19976926 | 0.86 | GRM4 (0.48) | DYRK1A | |
| SCHEMBL19976789 | 0.86 | GSK3B (0.42) | HDAC6DYRK1AMAPK1GSK3BCDK1 | |
| SCHEMBL19976781 | 0.84 | TRPA1 (0.35) | KDM4EDYRK1AABL1BCRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |