Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 6/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976730 | 0.87 | HDAC6 (0.41) | HDAC6MAPK10MAPK8GSK3BDAPK3 | |
| SCHEMBL19976800 | 0.87 | GSK3B (0.43) | HDAC6MAPK10MAPK8GSK3BDAPK3 | |
| SCHEMBL19976846 | 0.87 | KDM4E (0.42) | HDAC6MAPK10MAPK8ABL1BCR | |
| SCHEMBL19976731 | 0.85 | MAPK1 (0.42) | HDAC6MAPK8ABL1BCRGSK3B | |
| SCHEMBL19976886 | 0.83 | GSK3B (0.43) | HDAC6GSK3BGSK3ACYP1A2 | |
| SCHEMBL19976734 | 0.82 | MAPK10 (0.36) | HDAC6MAPK10MAPK8ABL1BCR | |
| SCHEMBL19976888 | 0.81 | GSK3B (0.51) | HDAC6MAPK10MAPK8GSK3BMAPKAPK5 | |
| SCHEMBL19976875 | 0.81 | HDAC6 (0.35) | HDAC6ABL1BCRGSK3BFLT4 | |
| SCHEMBL18558427 | 0.79 | KCNQ3 (0.35) | ABL1BCR | |
| SCHEMBL19976765 | 0.77 | NTRK1 (0.41) | HDAC6MAPK8GSK3BDAPK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |