Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976768 | 0.91 | MAPK1 (0.38) | MAPK1TRPA1EGFRHDAC6GSK3B | |
| SCHEMBL19976805 | 0.86 | ALDH1A1 (0.36) | MAPK1TRPA1GSK3BHPGDTSHR | |
| SCHEMBL19976781 | 0.85 | TRPA1 (0.35) | MAPK1TRPA1EGFRABL1BCR | |
| SCHEMBL19976731 | 0.85 | MAPK1 (0.42) | MAPK1HDAC6GSK3BFGFR1FGFR2 | |
| SCHEMBL19976812 | 0.84 | GSK3B (0.51) | MAPK1TRPA1HDAC6GSK3BFGFR1 | |
| SCHEMBL19976804 | 0.83 | TRPA1 (0.37) | TRPA1EGFRHDAC6GSK3BKDR | |
| SCHEMBL19976815 | 0.83 | GSK3B (0.44) | MAPK1TRPA1HDAC6GSK3B | |
| SCHEMBL19976858 | 0.82 | MAPK1 (0.46) | MAPK1HDAC6GSK3BFGFR1FGFR2 | |
| SCHEMBL19976764 | 0.81 | GSK3B (0.48) | MAPK1TRPA1HDAC6GSK3BFGFR1 | |
| SCHEMBL19976828 | 0.80 | GSK3B (0.49) | MAPK1TRPA1HDAC6GSK3BFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |