Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976739 | 0.92 | HPGD (0.37) | HPGDPOLBPRKD1ALDH1A1HTT | |
| SCHEMBL19976740 | 0.89 | HPGD (0.39) | HPGDPOLBPRKD1ALDH1A1AURKA | |
| SCHEMBL19976777 | 0.86 | POLB (0.39) | HPGDPOLBPRKD1MAPK1LMNA | |
| SCHEMBL19976851 | 0.84 | POLB (0.35) | HPGDPOLBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19976944 | 0.84 | MAPK1 (0.36) | HPGDPOLBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19976784 | 0.82 | MAPK1 (0.38) | POLBMAPK1 | |
| SCHEMBL19976880 | 0.80 | PDE10A (0.36) | HPGDPOLBMAPK1LMNA | |
| SCHEMBL9921120 | 0.80 | HPGD (0.37) | HPGDPOLBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19976909 | 0.78 | POLB (0.34) | HPGDPOLBALDH1A1HTTMAPK1 | |
| SCHEMBL16752808 | 0.77 | GSK3B (0.48) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |