Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | TEK | Q02763 | 2/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.33 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PTGFR | P43088 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976944 | 0.94 | MAPK1 (0.36) | POLBMAPK1NAMPTPDE2AHTT | |
| SCHEMBL19976777 | 0.88 | POLB (0.39) | POLBMAPK1NAMPTKMT2AHPGD | |
| SCHEMBL19976798 | 0.87 | PTGES (0.36) | POLBMAPK1KDM4EKMT2AALDH1A1 | |
| SCHEMBL19976784 | 0.85 | MAPK1 (0.38) | POLBMAPK1NAMPTMAP2K4 | |
| SCHEMBL19976928 | 0.85 | CTNNB1 (0.37) | POLBMAPK1CTNNB1TCF7L2HTT | |
| SCHEMBL19976727 | 0.84 | GSK3B (0.36) | MAPK1CACNA1HPDE2APTGFRGPR139 | |
| SCHEMBL16752809 | 0.84 | GSK3B (0.48) | MAPK1TRPA1MAP2K4MAPK6 | |
| SCHEMBL16752811 | 0.84 | GSK3B (0.48) | MAPK1TRPA1MAP2K4MAPK6 | |
| SCHEMBL16752808 | 0.84 | GSK3B (0.48) | MAPK1TRPA1MAP2K4MAPK6 | |
| SCHEMBL19976737 | 0.84 | HPGD (0.35) | POLBMAPK1HTTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |