Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 2/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976739 | 0.93 | HPGD (0.37) | HPGDLMNAMAPK1POLBHTR5A | |
| SCHEMBL19976737 | 0.89 | HPGD (0.35) | HPGDLMNAMAPK1ROCK2ROCK1 | |
| SCHEMBL19976777 | 0.86 | POLB (0.39) | HPGDLMNADGAT2MAPK1POLB | |
| SCHEMBL19976784 | 0.82 | MAPK1 (0.38) | DGAT2MAPK1POLB | |
| SCHEMBL19976759 | 0.81 | LMNA (0.36) | HPGDLMNADGAT2MAPK1POLB | |
| SCHEMBL19976880 | 0.81 | PDE10A (0.36) | HPGDLMNAMAPK1POLB | |
| SCHEMBL19362794 | 0.81 | RAB9A (0.47) | LMNAROCK2ROCK1KDM4EALDH1A1 | |
| SCHEMBL19976944 | 0.80 | MAPK1 (0.36) | HPGDLMNAMAPK1POLBKDM4E | |
| SCHEMBL19976851 | 0.80 | POLB (0.35) | HPGDLMNAMAPK1POLBKDM4E | |
| SCHEMBL18558416 | 0.79 | RAB9A (0.37) | HPGDLMNAMAPK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |