Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976740 | 0.93 | HPGD (0.39) | HPGDPOLBPRKD1AURKARPS6KB1 | |
| SCHEMBL19976737 | 0.92 | HPGD (0.35) | HPGDPOLBPRKD1AURKARPS6KB1 | |
| SCHEMBL19976777 | 0.89 | POLB (0.39) | HPGDPOLBPRKD1MAPK1LMNA | |
| SCHEMBL19976784 | 0.84 | MAPK1 (0.38) | POLBMAPK1 | |
| SCHEMBL19976880 | 0.83 | PDE10A (0.36) | HPGDPOLBMAPK1LMNA | |
| SCHEMBL19976944 | 0.82 | MAPK1 (0.36) | HPGDPOLBMAPK1LMNAKMT2A | |
| SCHEMBL19976851 | 0.82 | POLB (0.35) | HPGDPOLBMAPK1LMNAKMT2A | |
| SCHEMBL19976909 | 0.80 | POLB (0.34) | HPGDPOLBMAPK1LMNARAB9A | |
| SCHEMBL18558632 | 0.80 | RAB9A (0.47) | MAPK1LMNAMEN1KMT2ARAB9A | |
| SCHEMBL19362791 | 0.80 | RAB9A (0.39) | POLBMAPK1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |