Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976857 | 0.90 | MAPK1 (0.35) | TRPA1AURKARPS6KB1KDM4EHTT | |
| SCHEMBL19976804 | 0.86 | TRPA1 (0.37) | TRPA1AURKARPS6KB1EGFRDYRK1A | |
| SCHEMBL19976782 | 0.85 | MAPK1 (0.36) | TRPA1EGFRKDM4EABL1BCR | |
| SCHEMBL19976846 | 0.84 | KDM4E (0.42) | KDM4EABL1BCRMAPK1DYRK1A | |
| SCHEMBL19976767 | 0.82 | GSK3B (0.51) | TRPA1LMNATP53MAPTMAPK1 | |
| SCHEMBL19976854 | 0.82 | GSK3B (0.42) | TRPA1LMNATP53MAPTMAPK1 | |
| SCHEMBL19976766 | 0.80 | ABL1 (0.43) | AURKARPS6KB1EGFRKDM4EHTT | |
| SCHEMBL19976866 | 0.80 | DYRK1A (0.42) | AURKAMAPK1DYRK1A | |
| SCHEMBL19976780 | 0.80 | LMNA (0.33) | KDM4EHTTNPSR1ABL1BCR | |
| SCHEMBL19976776 | 0.79 | GSK3B (0.48) | TRPA1MAPK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |