Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 15/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976857 | 0.88 | MAPK1 (0.35) | MAPK1DYRK1AMAPK3TRPA1HDAC6 | |
| SCHEMBL19976801 | 0.86 | TRPA1 (0.37) | MAPK1DYRK1ATRPA1HDAC6PLK4 | |
| SCHEMBL19976768 | 0.81 | MAPK1 (0.38) | MAPK1DYRK1ATRPA1HDAC6PLK4 | |
| SCHEMBL19976805 | 0.80 | ALDH1A1 (0.36) | MAPK1DYRK1ATRPA1PLK4MAPK13 | |
| SCHEMBL19976769 | 0.79 | GSK3B (0.51) | MAPK1DYRK1ATRPA1HDAC6MAPK8 | |
| SCHEMBL19976781 | 0.78 | TRPA1 (0.35) | MAPK1DYRK1ATRPA1 | |
| SCHEMBL19976804 | 0.77 | TRPA1 (0.37) | DYRK1ATRPA1HDAC6PLK4MAPK13 | |
| SCHEMBL19976846 | 0.75 | KDM4E (0.42) | MAPK1DYRK1AHDAC6PLK4MAPK13 | |
| SCHEMBL9920713 | 0.75 | CCNA2 (0.40) | MAPK1CDK2PRKAA1NR1H4 | |
| SCHEMBL9939792 | 0.74 | CES1 (0.35) | MAPK1MAPK3MAP4K4CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |