Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 8/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976846 | 0.90 | KDM4E (0.42) | DYRK1AGSK3BDAPK3MAP4K4PIM1 | |
| SCHEMBL19976854 | 0.89 | GSK3B (0.42) | DYRK1ANTRK1GSK3BDAPK3MAP4K4 | |
| SCHEMBL19976789 | 0.87 | GSK3B (0.42) | DYRK1AGSK3BCDK2CDK1CYP1A2 | |
| SCHEMBL19976776 | 0.86 | GSK3B (0.48) | DYRK1AGSK3BMAP2K4CYP1A2MAPK1 | |
| SCHEMBL19976767 | 0.84 | GSK3B (0.51) | GSK3BMAPK8MAPKAPK5MAP2K4CYP1A2 | |
| SCHEMBL19976765 | 0.84 | NTRK1 (0.41) | DYRK1ANTRK1GSK3BDAPK3MAP4K4 | |
| SCHEMBL19976926 | 0.84 | GRM4 (0.48) | DYRK1A | |
| SCHEMBL19976766 | 0.83 | ABL1 (0.43) | DYRK1ANTRK1GSK3BDAPK3MAP4K4 | |
| SCHEMBL19976857 | 0.83 | MAPK1 (0.35) | DYRK1AGSK3BDAPK3MAP4K4PIM1 | |
| SCHEMBL19976745 | 0.82 | GSK3B (0.45) | DYRK1AGSK3BPIM1CDK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |